Can I Take These?

Can You Take Amlodipine and Ibuprofen Together?

No documented interaction was identified between amlodipine and ibuprofen in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Amlodipine page and Ibuprofen page for other reviewed interactions and reference information.

What the interaction means

Amlodipine's FDA prescribing information (Norvasc), including a full-text search of the entire document, does not mention NSAIDs, ibuprofen, or anti-inflammatory drugs anywhere; its Section 7 Drug Interactions covers only CYP3A inhibitors/inducers, sildenafil, simvastatin, and immunosuppressants. Ibuprofen's own FDA prescribing information and MedlinePlus page, both checked with a full-text search, do not mention amlodipine or calcium channel blockers anywhere.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions. NSAIDs' documented effect on blunting antihypertensive control is FDA-labeled for ACE inhibitors and ARBs (reflected elsewhere in this catalog for lisinopril and losartan), but that specific warning does not appear on amlodipine's own FDA label. Amlodipine and ibuprofen are commonly used together for blood pressure and pain management, but no direct pharmacological interaction between them is documented in the sources reviewed.

What the sources say

Amlodipine — MedlinePlus, U.S. National Library of MedicineIbuprofen Tablets, USP — FDA Prescribing Information — Ascend Laboratories, LLC (via DailyMed, U.S. National Library of Medicine)Ibuprofen — MedlinePlus, U.S. National Library of MedicineNorvasc (Amlodipine Besylate) Tablets — FDA Prescribing Information — Pfizer Laboratories Division, Pfizer Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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