Can I Take These?

Can You Take Amlodipine and Metformin Together?

Metformin's FDA label names calcium channel blockers -- the drug class amlodipine belongs to -- among medications that can raise blood sugar.

MonitorEvidence: Moderate

See the full Amlodipine page and Metformin page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA prescribing information states, in its Drug Interactions section: "Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control... Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid." Amlodipine is a dihydropyridine calcium channel blocker, per its own FDA label.

Why it may happen

Not further specified by the metformin label beyond classifying calcium channel blockers, as a pharmacologic class, among drugs that can raise blood glucose and reduce glycemic control.

Practical context

This mention is at the drug-class level in metformin's own label, not a study of amlodipine specifically, and amlodipine's own FDA label does not discuss glycemic effects. The metformin label instructs to "observe the patient closely for loss of blood glucose control" when such a drug is started, and to watch for hypoglycemia if it is stopped -- relevant if starting or stopping amlodipine in a patient on metformin.

What the sources say

Amlodipine Besylate Tablets, USP — FDA Prescribing Information — New Horizon Rx Group, LLC (Manufactured by Amneal Pharmaceuticals of NY, via DailyMed, U.S. National Library of Medicine)Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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