Can You Take Metformin and Spironolactone Together?
No documented interaction was identified between metformin and spironolactone in the sources reviewed.
What the interaction means
Metformin's FDA label does not mention spironolactone. Spironolactone's own FDA label does not mention metformin.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current FDA labels were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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