Can I Take These?

Can You Take Metformin and Spironolactone Together?

No documented interaction was identified between metformin and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Metformin page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label names 'thiazide and other diuretics' as affecting glycemic control, but spironolactone is a potassium-sparing diuretic (a distinct subclass) and is not named individually. Spironolactone's own 13-item drug-interaction list does not name metformin either.

No documented interaction between Metformin and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Metformin's and spironolactone's FDA labels were checked directly, full text, in both directions. Spironolactone's diuretic subclass was deliberately not assumed to be covered by metformin's generic 'other diuretics' phrase without a clearer statement naming it.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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