Can I Take These?

Can You Take Aspirin and Spironolactone Together?

Spironolactone's FDA label has a dedicated section stating that aspirin can reduce spironolactone's effectiveness.

MonitorEvidence: High

See the full Aspirin page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA prescribing information includes a subsection titled "7.6 Acetylsalicylic Acid," which states: "Acetylsalicylic acid may reduce the efficacy of spironolactone." A pharmacokinetic drug-interaction study cited in the label found that "A single dose of 600 mg of acetylsalicylic acid inhibited the natriuretic effect of spironolactone."

Why it may happen

Aspirin, particularly at higher anti-inflammatory doses, inhibits prostaglandin synthesis, which can blunt spironolactone's natriuretic (sodium-excreting) and diuretic effect -- the same general mechanism the label describes for NSAIDs as a class reducing spironolactone's "diuretic, natriuretic, and antihypertensive effect."

Practical context

The cited interaction study used a 600 mg aspirin dose, well above typical low-dose (81 mg) cardioprotective aspirin use, so the practical significance may be greatest with higher, anti-inflammatory-range aspirin dosing rather than daily low-dose aspirin. Anyone taking spironolactone for blood pressure or fluid management who also uses aspirin regularly, especially at higher doses, should discuss this with the prescriber managing their treatment, since reduced spironolactone efficacy could affect blood pressure or fluid control.

What the sources say

DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions