Aspirin
Aspirin (acetylsalicylic acid) is a salicylate available over-the-counter and by prescription, used to relieve pain, fever, and inflammation, and at low daily doses to help prevent heart attack and stroke.
What it is
Aspirin is a salicylate that works, per MedlinePlus, 'by blocking natural substances that cause fever, pain, swelling, and blood clots.' It is used for fever, mild-to-moderate pain and inflammation, and -- typically at low doses such as 81 mg -- to reduce the risk of heart attack, stroke, or death after a heart attack, by inhibiting platelet aggregation. Prescription extended-release aspirin products such as DURLAZA are FDA-indicated to reduce the risk of death and myocardial infarction in chronic coronary artery disease and to reduce the risk of death and recurrent stroke after an ischemic stroke or transient ischemic attack. Because aspirin inhibits platelet function and, at higher anti-inflammatory doses, shares mechanisms with other NSAIDs, its most consistently documented interactions in the sources reviewed involve bleeding risk with other antiplatelet/anticoagulant drugs and, at higher salicylate doses, renal and pharmacodynamic effects with certain other medications.
Food and timing considerations
Per MedlinePlus, aspirin is typically taken once a day for heart attack/stroke risk reduction, or every 4 to 6 hours as needed for fever or pain, following product-specific directions; extended-release tablets should be swallowed whole, not broken or crushed.
Known interaction categories
- Use caution
- Monitor
- Insufficient evidence
- Informational
Published interaction pages on this site
- Aspirin and SertralineUse caution
- Aspirin and LisinoprilMonitor
- Aspirin and WarfarinUse caution
- Aspirin and LevothyroxineMonitor
- Aspirin and AtorvastatinInsufficient evidence
- Aspirin and SpironolactoneMonitor
- Aspirin and CiprofloxacinInformational
- Aspirin and CaffeineInsufficient evidence
- Aspirin and CalciumInsufficient evidence
- Aspirin and CoQ10 (Coenzyme Q10)Insufficient evidence
- Aspirin and DoxycyclineInsufficient evidence
- Aspirin and MagnesiumInsufficient evidence
- Aspirin and MetforminInsufficient evidence
- Aspirin and PotassiumInsufficient evidence
- Aspirin and St. John's WortInsufficient evidence
- Aspirin and Vitamin B12Insufficient evidence
- Aspirin and Vitamin KInsufficient evidence
- Aspirin and CopperInsufficient evidence
- Aspirin and CreatineInsufficient evidence
- Aspirin and IronInsufficient evidence
- Aspirin and MelatoninInsufficient evidence
- Aspirin and OmeprazoleInsufficient evidence
- Aspirin and ProbioticsInsufficient evidence
- Aspirin and TurmericInsufficient evidence
- Aspirin and Vitamin DInsufficient evidence
- Aspirin and ZincInsufficient evidence
- Aspirin and AshwagandhaInsufficient evidence
- Aspirin and LosartanMonitor
- Aspirin and AmlodipineInsufficient evidence
- Aspirin and IbuprofenUse caution
- Aspirin and EscitalopramUse caution
- Aspirin and Vitamin CInsufficient evidence
- Aspirin and Omega-3 / Fish OilInsufficient evidence
- Aspirin and Vitamin EUse caution
- Aspirin and Folate / Folic AcidInsufficient evidence
Related guides
Sources
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.