Can I Take These?

Can You Take Aspirin and Melatonin Together?

NCCIH names blood thinner medications, a class aspirin belongs to, as needing medical supervision when combined with melatonin.

MonitorEvidence: Moderate

See the full Aspirin page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

NCCIH's melatonin safety page states: "people with epilepsy and those taking blood thinner medications need to be under medical supervision when taking melatonin supplements." No specific blood thinner is named, but aspirin is a well-established blood thinner (an antiplatelet drug, as distinct from anticoagulants like warfarin). Aspirin's own DURLAZA FDA label does not name melatonin in its Drug Interactions section.

Practical context

This is a class-level finding from melatonin's own safety information, not an aspirin-specific interaction study, and NCCIH does not explain the mechanism or give a dose threshold. Anyone taking aspirin regularly (especially at antiplatelet/cardioprotective doses) who is considering melatonin should mention it to their prescriber, consistent with NCCIH's own instruction to use medical supervision.

What the sources say

DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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