Can I Take These?

Can You Take Losartan and Melatonin Together?

No documented interaction was identified between losartan and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Losartan page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

Losartan's FDA label does not mention melatonin. NCCIH's melatonin fact sheet does not mention losartan, ARBs, angiotensin, or blood pressure medications.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Losartan Potassium Tablets — FDA Prescribing Information — Bryant Ranch Prepack (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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