Can I Take These?

Can You Take Melatonin and Warfarin Together?

NCCIH names blood thinner medications, a class warfarin belongs to, as needing medical supervision when combined with melatonin.

MonitorEvidence: Moderate

See the full Melatonin page and Warfarin page for other reviewed interactions and reference information.

What the interaction means

NCCIH's melatonin safety page states: "people with epilepsy and those taking blood thinner medications need to be under medical supervision when taking melatonin supplements." Warfarin is the textbook anticoagulant ("blood thinner"), so this class-level statement applies even though warfarin is not named by name. Warfarin's own FDA label's only "melatonin" occurrence is "MELATONIN RECEPTOR AGONIST" inside its generic pharmacologic-class taxonomy list -- a reference vocabulary entry, not an interaction statement.

Practical context

This is a class-level finding from melatonin's own safety information, not a warfarin-specific interaction study, and NCCIH does not explain the mechanism, name warfarin specifically, or give a dose threshold. Anyone taking warfarin who is considering melatonin should mention it to their prescriber and be alert to signs of a change in bleeding/clotting risk, consistent with NCCIH's own instruction to use medical supervision.

What the sources say

Warfarin Sodium Tablets — FDA Prescribing Information — Amneal Pharmaceuticals LLC (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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