Can I Take These?

Can You Take Caffeine and Spironolactone Together?

No documented interaction was identified between caffeine and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Caffeine page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

MedlinePlus's caffeine page does not mention spironolactone. Spironolactone's FDA label names 13 drugs/classes (potassium-increasing agents, ACE inhibitors, ARBs, NSAIDs, heparin, lithium, digoxin, cholestyramine, aspirin, and others) -- caffeine is not among them.

No documented interaction between Caffeine and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Caffeine's MedlinePlus page and spironolactone's FDA label were checked directly, full text, in both directions. Caffeine is not among spironolactone's 13 named interaction concerns.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Caffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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