Can I Take These?

Can You Take Levothyroxine and Metformin Together?

No documented interaction was identified between levothyroxine and metformin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Levothyroxine page and Metformin page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk -- levothyroxine is not among them. Levothyroxine's own extensive drug-interaction section (absorption, protein-transport, and metabolism effects) does not name metformin.

No documented interaction between Levothyroxine and Metformin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Metformin's and levothyroxine's FDA labels were checked directly, full text, in both directions. Neither drug is named in the other's drug-interaction section.

What the sources say

Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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