Can You Take Folate / Folic Acid and Levothyroxine Together?
No documented interaction was identified between folate and levothyroxine in the sources reviewed.
See the full Folate / Folic Acid page and Levothyroxine page for other reviewed interactions and reference information.
What the interaction means
Folate's NIH fact sheets do not mention levothyroxine. Levothyroxine's FDA label does not mention folate or folic acid.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Folate / Folic Acid and DoxycyclineInsufficient evidence
- Folate / Folic Acid and LisinoprilInsufficient evidence
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- Folate / Folic Acid and SertralineInsufficient evidence
- Folate / Folic Acid and St. John's WortInsufficient evidence
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- Folate / Folic Acid and Vitamin KInsufficient evidence
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- Folate / Folic Acid and Vitamin CInsufficient evidence
- Folate / Folic Acid and Omega-3 / Fish OilInsufficient evidence
- Folate / Folic Acid and AshwagandhaInsufficient evidence
- Folate / Folic Acid and Vitamin EInsufficient evidence
- Folate / Folic Acid and LosartanInsufficient evidence
- Folate / Folic Acid and AmlodipineInsufficient evidence
- Folate / Folic Acid and EscitalopramInsufficient evidence
- Folate / Folic Acid and AspirinInsufficient evidence
- Folate / Folic Acid and IbuprofenInsufficient evidence
- Levothyroxine and CalciumUse caution
- Levothyroxine and AtorvastatinInsufficient evidence
- Levothyroxine and IronUse caution
- Levothyroxine and CiprofloxacinInsufficient evidence
- Levothyroxine and SertralineMonitor
- Levothyroxine and Vitamin DInsufficient evidence
- Levothyroxine and WarfarinInsufficient evidence
- Levothyroxine and CreatineInsufficient evidence
- Levothyroxine and SpironolactoneInsufficient evidence
- Levothyroxine and St. John's WortInsufficient evidence
- Levothyroxine and CaffeineInsufficient evidence
- Levothyroxine and Vitamin KInsufficient evidence
- Levothyroxine and Vitamin B12Insufficient evidence
- Levothyroxine and CopperInsufficient evidence
- Levothyroxine and ZincInsufficient evidence
- Levothyroxine and PotassiumInsufficient evidence
- Levothyroxine and Vitamin CInsufficient evidence
- Levothyroxine and LisinoprilInsufficient evidence
- Levothyroxine and TurmericInsufficient evidence
- Levothyroxine and CoQ10 (Coenzyme Q10)Insufficient evidence
- Levothyroxine and DoxycyclineInsufficient evidence
- Levothyroxine and OmeprazoleMonitor
- Levothyroxine and MagnesiumMonitor
- Levothyroxine and MetforminInsufficient evidence
- Levothyroxine and MelatoninInsufficient evidence
- Levothyroxine and ProbioticsInsufficient evidence
- Levothyroxine and Omega-3 / Fish OilInsufficient evidence
- Levothyroxine and Vitamin EInsufficient evidence
- Levothyroxine and AshwagandhaMonitor
- Levothyroxine and LosartanInsufficient evidence
- Levothyroxine and AspirinMonitor
- Levothyroxine and AmlodipineInsufficient evidence
- Levothyroxine and EscitalopramInsufficient evidence
- Levothyroxine and IbuprofenInsufficient evidence