Can I Take These?

Can You Take Ibuprofen and Vitamin B12 Together?

No documented interaction was identified between ibuprofen and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Ibuprofen page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

Ibuprofen's own FDA label does not name vitamin B12 anywhere in its Drug Interactions section. The NIH ODS vitamin B12 fact sheet does not mention ibuprofen or NSAIDs; its interactions section names gastric acid inhibitors and metformin.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsIbuprofen Tablets, USP — FDA Prescribing Information — Ascend Laboratories, LLC (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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